Speaker: Gary Siuzdak, The Scripps Research Institute, La Jolla, CA

Topic: Porous Silicon as a Versatile Platform for Biomolecule Laser Desorption/Ionization Mass Spectrometry

Place: Building 426, Conference Room, NCI-Frederick, Frederick, MD

Time: Tuesday, August 8, 2000, at 2:00 PM

Abstract: Desorption/ionization on porous silicon mass spectrometry (DIOS-MS) is a novel method for generating and analyzing gas phase ions that employs direct laser vaporization. The structure and physicochemical properties of the porous silicon surfaces are crucial to DIOS-MS performance and are controlled by the selection of silicon and the electrochemical etching conditions. The application of DIOS to small molecules, quantitative analysis, organic reaction monitoring, proteomics, post-source decay mass spectrometry, and chromatography will be described. For a brief description of the technique, see: Wei, Buriak, and Siuzdak, Nature 399, 243-246 (1999).