Mass Spectrometry Interest Group of the NCI at Frederick

Picture of the seminar speaker, Sonja Hess, Ph.D.

Sonja Hess

National Institute of Diabetes and Digestive and Kidney Diseases - NIH

Office: 301-402-2197
FAX: 301-402-1967
E-mail: sonjah@intra.niddk.nih.gov

Job Title: Scientist
Ph.D. in Medicinal Chemistry
from the University of Leipzig, Germany

Speaker: Sonja Hess, Structural Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20894

Topic: Mass Spectrometric Characterization of Fimbriae of Gram Negative and Gram Positive Bacteria

Place: Building 426, Conference Room, NCI at Frederick, Frederick, MD

Time: Tuesday, July 22, 2003, at 2:00 PM

Abstract: Fimbriae are proteinaceous hair-like structures that mediate the adhesion of bacteria to host tissue surfaces. Due to their high hydrophobicity, fimbrial proteins are considered notoriously difficult to analyze and are not amenable to standard proteomics techniques such as liquid chromatography - mass spectrometry. However, mass spectrometry is the predominant proteomics technique to catalog and characterize proteins, their variants and post-translational modifications. Therefore, the focus of our study is the development of mass spectrometry techniques that will enable us to characterize fimbriae of gram negative and gram positive bacteria.

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Updated 22-July-2003