Jim O. Samuelsson Genedata Office: +49 (0)89 895 110217 FAX: +49 (0)89 895 110215 E-mail: jim.samuelsson@genedata.com Job Title: Scientist Ph.D. in Theoretical Physics from the University of Lund

Jürgen H. Cox Genedata Office: +49 (0)89 895 110216 FAX: +49 (0)89 895 110215 E-mail: juergen.cox@genedata.com Job Title: Scientist Ph.D. in Physics from the Massachusetts Institute of Technology

Speaker: Jim Samuelsson and Jürgen Cox, Genedata, Martinsried, Germany

Topic: Automated Biomarker Detection and Identification of Biomolecules Using Mass Spectrometry Data

Place: Building 549, Auditorium, NCI at Frederick, Frederick, MD

Time: Thursday, June 23, 2005, at 2:30 PM

Abstract: Advances in Mass spectrometry (MS) now provide the possibility for sensitive high throughput biomolecule profiling of complex compound mixtures. We describe a highly automated workflow for high throughput MS data refinement and analysis. Developed in close collaboration with industrial and scientific partners, the workflow is implemented within an integrated bioinformatics platform and can be applied to proteomic as well as metabolomic data, and with all major technology configurations. We illustrate the workflow with an example from proteomics, using data acquired by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).