David Newman National Cancer Institute Office: 301-846-5387 FAX: 301-846-6178 E-mail: newman@dtpax2.ncifcrf.gov Job Title: Chemist Ph.D. in Microbial Chemistry from the University of Sussex

Speaker: David Newman, Natural Products Branch, National Cancer Institute, Frederick, MD 21701

Topic: The Staurosporin Nucleus, a Molecule (!) for All Diseases - Video (running time 00:39:30) ^*

Place: Building 549, Auditorium, NCI at Frederick, Frederick, MD

Time: Tuesday, May 14, 2002, at 2:00 PM

Abstract: Although staurosporin was originally identified as a PKC inhibitor, the more targets that this molecular scaffold has been exposed to, the more interesting it has become. Currently, there are staurosporin "look-alikes" in clinical trials as drug candidates for topoisomerase I and II inhibition and Cyclin-dependent kinase inhibition. Not areas that one would assume, a priori, that the same basic molecule would be involved. Some thoughts that come to mind involve the possibilities for using such molecules as probes for targets and then the use of sensitive mass spectrometric techniques might well be able to show commonalities in binding sites, thus leading to improved designs for both screens and molecules. These areas will be discussed from both a natural product and also a synthetic perspective.

The slides to this seminar are in a 0.9 Megabyte PDF file, which can be opened and read by using the free Adobe Acrobat Reader®.

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