Rudolf Grimm Agilent Technologies Deutschland GmbH Office: +49 (07243) 602 853 FAX: +49 (07243) 602 501 E-mail: rudolf_grimm@agilent.com Job Title: Proteomics Market Development Manager Ph.D. in Biology from the University of Munich, Germany

Speaker: Rudolf Grimm, Agilent Technologies, Waldbronn, Germany

Topic: Systems Biology and Technology Advancements

Place: Building 549, Auditorium, NCI at Frederick, Frederick, MD

Time: Thursday, March 11, 2004, at 2:30 PM

Abstract: Systems biology is an emerging and exciting field dedicated to understanding the complexity of biological systems. Systems Biology is an integration of all the various "Omics" approaches such as transcriptomics, proteomics and metabolomics. Agilent Technologies is committed to provide advanced analytical solutions in all of these individual research areas. For example, for transcriptomics, new microarrays capable of probing the entire human genome allow the elucidation of all up- and downregulated transcripts. For proteomics, innovative nanoscale separation tools combined with mass spectrometry (Trap, TOF and ICP-MS) permit complex proteome samples to be automatically analysed. New prefractionation tools and tagging chemistries help to address the challenges associated with low-level protein analysis. For metabolomic studies, a broad range of analytical tools is provided. New bioinformatics software tools allow rapid data consolidation as well as integration and correlation of heterogeneous data sets for enhanced data mining. Together all of these tools make possible progress toward the goal of understanding how biological systems function and regulate in response to various perturbations. Examples of such perturbations include disease, drug treatment, aging, etc..