Alfred l. Yergey NICHD, NIH, Bethesda, MD 20892 Office: 301-496-5331 FAX: 301-480-5793 E-mail: aly@helix.nih.gov Web: Job Title: Chief, Section on Mass Spectrometry and Metabolism Ph.D. in Analytical Chemistry from the Pennsylvania State University

Speaker: Alfred L. Yergey, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892

Topic: Spectral Variability - What Might We Do with Better Mass Spectra?

Place: Building 549, Conference Room A, NCI at Frederick, Frederick, MD

Time: Tuesday, February 24, 2009, at 2:00 PM

Abstract: Variability in mass spectral data very likely is the basis of much of the current problems of reliability of proteomic data. While there is a fundamental variability in biological materials, beyond that there exists a variability in the mass spectra themselves that is all too commonly ignored. Issues of experimental variability are discussed and an approach to statistically quantify the variability in mass spectra is presented along with a demonstration of the improvement in results that it yields.

The slides to this seminar are in a 2.8 Megabyte PDF file, which can be opened and read by using the free Adobe Acrobat Reader®.