Ichiro Hirano Shimadzu Corporation, Tokyo, Japan Office: 81-3-3219-5588 FAX: 81-3-3218-5557 E-mail: i_hirano@shimadzu.co.jp Job Title: Assistant Manager (Mass Spectrometry) B.Sc. in Analytical Chemistry from the Hiroshima University

Speaker: Ichiro Hirano, Shimadzu Corporation, Tokyo, Japan

Topic: Component Identification Using a Quadrupole Ion Trap Time-of-Flight Mass Spectrometer

Place: Building 549, Conference Room A, NCI at Frederick, Frederick, MD

Time: Tuesday, January 29, 2008, at 2:00 PM

Abstract: Predicting a candidate list based on MS and MS^n data takes into account a number of variables, including mass accuracy and mass resolution of the experimentally derived pseudo-molecular peak and related fragment ion data generated using MS^n spectra (or complement ion data) together with conventional chemical rules (such as nitrogen, electron configuration, DBE range, H/C ratio). A new and uniquely designed instrument, the LCMS-IT-TOF, allows a researcher to exploit the advantages of an ion trap - the ability to collect MS^n data and a TOF - which allows for good mass accuracy and resolution across all MS^n modes. An overview on the design of this new LCMS-IT-TOF instrument will be discussed. This will be followed by examples of recent applications highlighting its utility and strengths.

Accompanying Poster: "Structural Elucidation by Composition Formula Predictor Software Using MS^n Data", authored by Holly M. Shackman, Joy M. Ginter, Joseph P. Fox, and Masayuki Nishimura of Shimadzu Scientific Instruments, Columbia, MD